Frequency of endometrial carcinoma in histopathology of hysterectomy specimen in Hyderabad

This study was conducted to find the frequency of endometrial carcinoma in histopathology specimens in Hyderabad. Descriptive study. All hysterectomy specimens received in the histopathology department of Isra University Hyderabad and Liaquat University of Medical and Health Sciences Hyderabad during the period of January 2005 to December 2006 were collected. A randomized study of 100 cases undergoing hysterectomy was carried out. Maximum number of women who underwent hysterectomy was in the age group of 25-75 years. Two proformas were designed to get the clinical information and gross and histopathological findings. Specimens were preserved in 10% formalin and thorough naked eye examination was done. Representative blocks were taken and processed for paraffin embedding out of 100 cases, endometrial carcinoma was found in 07 [7%] cases. Mean age of the patient was 43.06 +/- 7.34 years while the mean age of endometrial carcinoma was 50.71 +/- 9.32 years. Abnormal menstrual flow was the most common complaint. Most of the cases [N=06] were present in group B that is above the age of 40 years. Furthermore out of these 07 diagnosed cases, 06 cases were present in multiparous women while only one case was found in nulliparous woman. Frequency of endometrial carcinoma is 7% in women of Hyderabad. It is more common above the age of 40 years and in mlutiparous and grandmultiparous women

Evaluation of coagulation abnormalities in lung cancer patients

Objective: to determine the coagulation abnormalities in patients with lung cancer

Study design: case-control study

Place and duration: department of Pathology Isra University Hospital Hyderabad, Sindh - Pakistan, and Department of Medicine Liaquat University of Medical and Health Sciences Jamshoro, Sindh - Pakistan, from June 2006 to December 2007

Patients and methods: seventy subjects were recruited for the study by non-probability convenient sampling technique. Forty freshly diagnosed histopathology proven lung cancer patients were taken as cases, whereas 30 healthy subjects comprised the control group. Platelet count [PLT] was done on hematology analyzer while prothrombin time [PT], activated partial thromboplastin time [APTT] and plasma D-dimer tests were performed by commercially available kits at Department of Pathology, Isra University Hospital Hyderabad, and Sindh - Pakistan. T test was applied to determine the significance of differences between two groups whereas P value up to .05 was taken as significant

Results: the mean +/- SD PLT in cases and controls was 394 +/- 170 and 216 +/- 73 respectively. The mean +/- SD values for these respective groups were for PT 14.7 +/- 0.5 and 12.6 +/- 0.4, for APTT 41.5 +/- 6.2 and 25.8 +/- 3.7. D-dimer levels were <500 in all 30 controls whereas these were up to 2000 in cases

Conclusion: there is a strong relationship between coagulation abnormalities and lung cancer. D-dimer is very sensitive for evaluation of fibrinolysis related with lung cancer